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Biotin deficiency

Biotin plays a vital role in assisting enzymes to break down fats, carbohydrates and proteins in food. But a deficiency leads to dysbiosis of the gut and a reduction in mucus-resident microbes, in turn leading to characteristics of Inflammatory Bowel Disease.

That was the conclusion of research at the University of California into microbiome-favoured species that can synthesise biotin, a water-soluble B vitamin.

Biotin deficiencies are increasingly being linked to gut disorders including IBD and gut permeability, as well as colitis. The study was conducted in mice and opens the way for targeted interventions in humans with bowel diseases.

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